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Megaloblastic anemia literature review

Nutritional deficiencies especially vitamin B12 deficiency as a cause of fever, hemolytic anemia, and thrombocytopenia are very rare and therefore rarely thought of. Severe vitamin B12 deficiency may cause fever and if accompanied by concurrent hyper-homocysteinemia and hypophosphatemia can sometimes lead to severe hemolysis mimicking the above-mentioned conditions. We present a case that highlights vitamin B12 and vitamin D deficiency as an easily treatable cause of PUO, hemolytic anemia, and thrombocytopenia, which should be actively looked for and treated before proceeding with more complicated and expensive investigation or starting empiric treatments. Keywords: Fever, hemolytic anemia, homocysteine, hypophosphatemia, vitamin B12, vitamin D. Spectrum and analysis of bone marrow findings in anemic cases.
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Alpha-thalassemia

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Pure red cell aplasia - Wikipedia

Vitamins are the organic compounds required by the human body and are considered as vital nutrients needed in specific amounts. They cannot be synthesized in a sufficient amount by the human body; so, they must be obtained from the diet. Thirteen different types of vitamins are known that are classified by their biological and chemical activity. Each one of them has a specific role in our body. Folic acid has a vital role in cell growth and development through many reactions and processes that occur in the body, e. When the body becomes deficient in folic acid, all cycles that are mentioned above will become ineffective and lead to many problems, in addition to other problems such as megaloblastic anemia, cancer, and neural tube defects. Vitamin B12 has a vital role in cell growth and development through many reactions and processes that occur in the body.
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Sickle cell disease

Forgotten your password? Pernicious anaemia PA is an autoimmune disease of multifactorial aetiology involving environmental and immunological factors. It is the most common cause of cobalamin deficiency anaemia worldwide.
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