It was first noted in by Sharp et al. Connective tissue is the fibrous tissue that makes up the framework of your body. As the immune system attacks these tissues, they become inflamed causing soreness, pain and in some instances damage to the organs. MCTD occurs in people worldwide and in all races.
Managing Mixed Connective Tissue Disease Flares
Mixed connective tissue disease in children – case series
Mixed connective tissue disease MCTD is an autoimmune disease which was first described in by Sharp et al. Therefore, MCTD is sometimes referred to as an overlap disease. The initial presentation of the patients usually comprises non-specific signs such as swollen digits, arthralgia, myalgia or muscle weakness, acid reflux or dysphagia, Raynaud's phenomenon, shortness of breath on activity, a general malaise and fatigue. Over a period of time the symptoms are dominated by symptoms of either of one of the three illness along with high titers of anti-U1RNP antibody. The etiology of the mixed connective tissue disorder is unknown but being an autoimmune disease MCTD can run within families and is known to affect women more than men. No causal association and the varied presentation, makes the diagnosis of this rare condition difficult.
A case of mixed connective tissue disorder with interstitial lung disease: case report.
The literature reports that mixed connective tissue disease seems more frequent in the black population and among Asians. This study aims to determine the prevalence of mixed connective tissue disease MCTD among connective tissue disorders and all rheumatologic pathologies in a hospital population in Gabon as well as to describe the clinical features of this disease. We conducted a retrospective study by reviewing the medical records of patients treated for mixed connective tissue disease Kasukawa criteria and other entities of connective tissue disorders ACR criteria in the Division of Rheumatology at the University Hospital in Libreville between January and December Over a period of 6 years, data were collected by medical records of 7 patients out of patients and 67 cases of connective tissue disorders, reflecting a prevalence of 0.
In this original study, the portrait emerged of a connective tissue disorder sharing features of systemic lupus erythematosus, systemic sclerosis scleroderma and polymyositis. The histologic picture of SRC is that of a thrombotic micro-angiopathic process. Search Article. Users online: